Melatonin has a role in psychiatric illness and the treatment of circadian rhythm sleep disorders, insomnia, and comorbid depressive disorders. Melatonin was first isolated from the bovine pineal gland in It is produced from a pathway that includes both tryptophan and serotonin. Melatonin displays high lipid and water solubility, which allows it to diffuse easily through most cell membranes, including the blood-brain barrier. Its half-life is about 30 minutes, and it is cleared mostly through the liver and subsequently excreted in the urine as urinary 6-sulfatoxymelatonin. In humans and most diurnal mammals, melatonin is secreted at night with a robust circadian rhythm and maximum plasma levels that occur around 3 to 4 AM. The rhythmic release of melatonin is regulated by the central circadian rhythm generator-the suprachiasmatic nucleus SCN of the anterior hypothalamus. Most of the chronobiotic and hypnotic effects of melatonin are mediated through 2 receptors: MT1 and MT2. Both subtypes have high density in the SCN, but they are also spread throughout other sites in the brain and other organs, which indicates that melatonin likely affects other biological systems. The phase shifting effects of melatonin appear to be due to the MT2 receptor, while the MT1 receptor is more related to sleep onset.
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It was initially released in in Italy, then elsewhere the following year. The song is the title track of their debut studio album The Rhythm of the Night. The vocals for this song were performed by Italian singer Giovanna Bersola , who is not credited on the single and does not appear in the music video. It reached number-one in Italy and stayed there for eight consecutive weeks. In the end of it was the longest-charting single on the Eurochart Hot In the United States, it reached number eleven on the Billboard Hot
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It was a single from their fourth studio album, Rhythm of the Night on the Motown label. The song jump-started the career of the prolific Warren,  and was the biggest hit recorded by the Motown family singing group, peaking at number three on the Billboard Hot , prevented from further chart movement by Madonna 's " Crazy for You " and USA for Africa's " We Are the World ". Motown Records sought to produce DeBarge with a dance single to give them a bigger crossover success that mirrored that of label-mate Lionel Richie , who like DeBarge, had created his initial fan base on soft songs before the release of " All Night Long ", which included a catchy dance beat influenced by calypso. A similar influence would come in the production of "Rhythm of the Night" which featured more of El DeBarge's deep tenor with flashes of his trademark falsetto. Richard Perry , the hit producer behind hit recordings for The Pointer Sisters , Harry Nilsson , and Carly Simon , among others, was appointed to produce the single with Diane Warren as its writer. The release of "Rhythm of the Night" coincided with the release of the Motown film The Last Dragon , which featured the song as part of its soundtrack. The free publicity from the song on its soundtrack and in the movie itself helped boost its popularity. The group's music video of the song gained the group heavy rotation on MTV and BET and was actually the group's first and last real music video starting a brief period where DeBarge became pop superstars.